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Minor injury: 2–4 weeks at 250–500 mcg/day Severe injury or surgery: 4–6 weeks, up to 1,000 mcg/day Gut repair: 4–6 weeks oral or SubQ Neurological support: 4–8 weeks Response time varies, and there is not enough high-quality human evidence to promise improvement within a specific number of days, especially in pain reduction and mobility